What's Here — 

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One Discovery Square is an 81,000 square foot state-of-the-art life science building designed to foster collaboration and innovation. It is professionally programmed to create a culture of collaboration with building amenities that are strategically designed to foster an interactive culture and generate structured serendipity with an advanced healthcare innovation ecosystem. One Discovery Square is a building that fosters knowledge. It is a place where collaboration is key and working together is the norm.


With Mayo Clinic at its core, One Discovery Square is THE ONLY collaborative model in which higher education, startups and Mayo Clinic's partner companies can work together in the same space. Specially built to support healthcare innovation, the campus features:

  • Specialized event programming by the Musicant Group

  • Collaborative team spaces

  • Multiple shared conference rooms per floor

  • Onsite cafe

  • Multiple common areas with shared courtyard

  • Infrastructure for wet, dry labs, GMP facilities

  • Access to retail, restaurants, hotels and services

“This is an exciting project for Rochester. The Destination Medical Center and its sub-districts will stand as an example for the city of the future—a re-imagined home for innovation. For the community, state of Minnesota and leaders in the life science industry, this major achievement will transcend the previously established limits of how we define dimensional access to health and wellness.”
- Andre Terzic, M.D., Ph.D., Director, Center for Regenerative Medicine, Mayo Clinic



4th Floor

3rd Floor

2nd Floor

1st Floor

  • Mayo Clinic - Advanced Diagnostics & Regenerative Medicine

  • University of Minnesota Rochester - Classrooms & Lab

  • Wuxi Diagnostics

  • Mayo Clinic - Ultrasound Imagery & Artificial Intelligence

  • Phillips

  • Motion Medical by Boston Scientific

  • Epic

  • University of Minnesota Rochester

  • Café Steam

  • Mayo Clinic - Regenerative Medicine

  • RION


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'Define' Conference Room

'Ideate' Conference Room

'Prototype' Conference Room

'Implement' Conference Room

Conference Room

For more information about development at
 Discovery Square and leasing opportunities please contact Louis Suarez.

VP Healthcare Services
Colliers International Minneapolis-St. Paul
Direct: 952-837-3061
Mobile: 651-260-2412

202 4th Street SW, Rochester, MN 55902

One Discovery Square is a proud member of the