Campus Amenities



One Discovery Square is laser-focused on fostering a culture of collaboration between tenants and the outside business, research and Rochester communities. Our professionally programmed common areas have become epicenter for cross-sector meetings, brainstorming sessions, lunch-and-learns from industry leaders, creative "left brain" programming, networking events and your next big breakthrough. Our programmed spaces generate structured serendipity where collaboration is in the air and working together is the norm.
At One Discovery Square, you'll find:
  • 10-15 events a week that bring the Mayo Clinic, business, research and Rochester communities to your doorstep
  • Onsite event planning services to help your company plan their next event, from team lunches to product launches
  • Multiple conference and breakout rooms throughout the building to support any size of meeting
  • The best coffee in Rochester at Café Steam
  • Flexible training and conference center for up to 125 people
  • Multiple common areas with shared courtyard
Examples of events:
  • Biweekly TGIM (Thank God It's Monday) free breakfast gatherings for tenants
  • Monthly happy hours that are quickly becoming the "must-attend" event in Rochester
  • Wellness Wednesdays — a rotating array of yoga, massage, meditation and more
  • LeaderSHARE — a quarterly gathering with leaders from each tenant
  • Weekly Left Brain programming focused on creativity in partnership with UMR
  • Food Truck Fridays
  • 1 Million Cups entrepreneurship gathering every month
  • Taco Bout Innocation lunch-and-learns
  • Lunches with Ted — monthly TED Talk luncheons


One Discovery Square houses a best-in-class programming, events and community management program that fosters a culture of collaboration and innovation. One Discovery Square's design and daily operations are engineered to deliver new relationships, innovations and enterprises for and between tenants and the broader medical, technology, business and civic communities. This is delivered through a holistic set of services set by nationally recognized activation firm The Musicant Group, tailored to the district tenant mix and mission of Discovery Square.

Check out our successful past events!



As a business operating in One Discovery Square, you will have meetings with Mayo Clinic Ventures staff for routine reviews of new intellectual property. The collaboration can extend to opportunities for evaluation and co-development of new and existing technologies with input from distinguished clinicians and scientists.

One Discovery Square businesses have a strategic workforce advantage. Mayo Clinic College of Medicine and Science offers cutting edge programs in biomedical research, medical and clinical education. World-class faculty have the ability to tailor innovative training and curriculum to meet companies' evolving staffing needs.

Tenants at One Discovery Square have access to many of Mayo Clinic's Core Services, including:

Genome Analysis Core

  • Genome, Exome and Transcriptome Sequencing

  • Genotyping

  • Gene Expression 



  • Nucleic Acid Extraction

  • Plasma/Serum Separation

Immunochemical Core Lab

  • Mass Spec, Cobas, Elisa and RIA Platforms for Small Molecule Analysis and Other Analytes

Metabolomics Core

  • Mass Spectrometers, Liquid and Gas Chromatography Platforms to Identify and Analyze Metabolites

Microscopy and Cell Analysis Core

  • Electron Microscopy

  • Light Microscopy

  • Flow Cytometry

Pathology Research Core

  • Sectioning Both Paraffin-Embedded and Frozen Tissues

  • Automated Staining for Immunohistochemistry, Immunofluorescence and RNA in Situhybridization

  • Tissue Microarray Construction with 60 to 360 Cores

  • Digital Analysis of Whole Tissue and TMA Slides

Other core laboratory resources could be available.

Please contact Chris Kolbert,, for more information.




Collaboration Hall

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Outside Patio


2nd Floor Area


3rd Floor Area








Café Steam is a locally-owned, independent coffee shop located in the Discovery Square Campus and just a few minutes’ walk from Mayo Clinic in downtown Rochester, Minnesota. Home to the best coffee in Rochester, Café Steam opened in 2015 with the vision to create a café that catered to the Rochester community, as well as a place for local artists and musicians to showcase their creative talents. 

Upcoming Events at One Discovery Square:

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Bike Storage — Additional coming in Discovery Square 2

Showers — Additional coming in Discovery Square 2

Multiple patio courtyards — Additional courtyards in Discovery Square 2

Large conference/training facility for over 100 people — Coming soon to Discovery Square 2

Multiple conference rooms — Additional conference rooms in Discovery Square 2

Building link — Atrium link between both buildings

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For more information about building programming and opportunities, 

please contact Jessica Pickering 952-380-7736.

For building management inquiries, please contact Elliott Clark 651-497-8564.

For leasing inquiries, please contact Louis Suarez 952-837-3061.

Community Event Manager
The Musicant Group

Propety Manager
Colliers International

VP Healthcare Services
Colliers International

202 4th Street SW, Rochester, MN 55902

One Discovery Square is a proud member of the